The Biggest Scientific Story that is Too Obvious To See

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The Biggest Scientific Story that is Too Obvious To See

Postby Tom Hendricks » Tue Feb 09, 2010 1:33 pm

By looking at evolution as 2 often separate paths of either:
CATABOLISM and all other breaking down chemical processes, and
ANABOLISM and all other building up chemical processes;
one can see these possible

DIVISIONS - See part one

DISCOVERIES - See part two.


C= Catabolic A= Anabolic

PART ONE DIVISIONS:

1. OVERALL. C. anything that defends A. anything that nurtures

2.CATABOLIC GROUP: Catabolic chemical processes are those that mostly evolved to include, digestion, protection (digestion of non self), waste out (excretion of digested non-self waste).

3. FOOD IN / WASTE OUT. C - Waste out - blocked out or excreted out. A - Food in - taken in or held in.

4. DIGESTION AND ABSORPTION. C - digestion. A - absorption and assimilation.

5. HETEROTROPHS / AUTOTROPHS. C - Heterotrophs (animals, fungi, etc.) A - Autotrophs (plants etc.).

6. WAKE / SLEEP: Wake is the first half of a daily metabolic cycle. Sleep is the 2nd half of a daily metabolic cycle. C - Wake and the end of sleep, REM sleep. A - Deep Sleep, all stages.

7. CIRCULATORY SYSTEM. C - Lymphatic System, white blood cells. A - Circulatory System, red blood cells.

8. PHOTOSYNTHESIS. C - Light reaction. A. -Dark reaction.

9. SEX: C - Male like behavior A. - Female like behavior.

10. HUNTER - GATHERERS C - Hunter. A - Gatherer.

11. AGGRESSION, VIOLENT BEHAVIOR, WAR. C - Mostly repressed inner conflicts of, not all humans but MALE humans.

12. FIGHT AND FLIGHT. C - Male type behavior.

13. TEND AND BEFRIEND. A - Female type behavior.

14. CELL DEATH . REPLICATION. C - Cell death. A - cell replication.

15. CELL CYCLE. IN EUKARYOTES. C - Mitotic phase (mitosis and cytokinesis). A - interphase.

16. KAREN HORNEY'S 3 TYPES OF INNER CONFLICTS. C - Moves against others, Moves away from others. A - Moves towards others.

17. RELATION TO OTHER ORGANISMS. C - antibiosis. A - Symbiosis.
Social relationships are projection of the Catabolic and Anabolic push and pull of the individual on to group dynamics.\

18. DIRECTION OF EVOLUTION. Natural selection for better C. or A.

19. MOTOR TO EVOLUTION. C improvement will bring pressure on A processes to improve, and vice versa. So there is a drive to match each positive change on one side to the other. Most positive changes on either side would bring a 2nd improvement on the other - thus two changes for one. In many cases natural selection would be doubled.

20. AUTOIMMUNE DISEASES . Catabolic problem - self digest self, instead of self digest non self.

21. EMOTIONAL DEVELOPMENT. C - Anger, Fear. A - neediness, hunger.

22. ORIGIN OF LIFE CLUE . Two part C/A processes seem to be a reaction to a two part cycle in the environment such as Day/Night and , or Dry/Wet.

23. ORIGIN OF LIFE CLUE 2 C - Night, No sunlight - UV, wet, hydrolysis of ATP, type chemistry. A - Day, sunlight-UV, dry condensation synthesis, type processes.

________________________________



PART TWO DISCOVERIES

IF all life evolved in one of two ways - either better catabolism or better anabolism, then that may begin to explain these things:

How life has evolved in only two specific separate pathways, anabolic and catabolic.
Why we have two sexes
Why males are the more aggressive sex. Why protective male behavior.
Why violent behavior is mostly a male behavior.
Why females are the more nurturing sex. Why nurturing female behavior.
Why males react to stress with fight or flight
Why females react to stress with tend and defend

That there is a daily metabolism cycle.
That the daily metabolism cycle has two parts - wake and sleep.
That wake is more concerned with catabolic processes
That sleep is more concerned with anabolic processes
That there may be two relatively separate minds in humans, not one; catabolic mind, and an anabolic mind.
That the wake mind may be the catabolic mind (conscious mind?)
That the sleep mind may be the anabolic mind. (unconscious mind?)
That in sleep the NREM or deep sleep (80%) is for replenishing the body (anabolic).
That in sleep the REM or dream sleep (20%) is for preparing waste out (catabolic).

That growth has an anabolic temperature that is high, and a catabolic temperature that is low.
That loss (opposite of growth) has an anabolic temperature that is low, and a catabolic temperature that is high.
That overweight is a catabolic temperature that is too low, and/or an anabolic temperature too high. The person often feels too warm
That underweight is a catabolic temperature that is too high, and/or an anabolic temperature too low. The person often feels too cold.
That the only true way to adjust weight (loosing or gaining) is to adjust the catabolic / anabolic temperatures.
Why women are more prone to weight problems then men.
Why loosing or gaining weight is so difficult to do.
That looking at catabolic temperature, versus anabolic temperature, can now be a diagnostic tool for Doctors.
That too high a catabolic temperature, and too low an anabolic temperature, has certain specific health and psychological problems.
That these problems can be resolved by adjusting the catabolic / anabolic temperature.

That the Sympathetic Nervous system (fight and flight) evolved out of Catabolic processes.
That the Parasympathetic Nervous System (rest and digest) evolved out of the Anabolic processes.
That there are two basic types of hormones: Catabolic, and Anabolic hormones.
That Anger and Fear are the main two catabolic emotions. (Fight or flight).
That Hunger and Neediness are the main anabolic emotions. (Tend or befriend).

That the three major inner conflicts outlined by Karen Horney in "Inner Conflicts" are reflections of anabolic or catabolic behavior with anabolic being "Move towards others" behavior, and catabolic being "Move against others' behavior, AND "Move away from others' behavior.
That her groundbreaking book missed the fourth. "Move towards self" (anabolic).
That food in waste out is a reflection of anabolism (food in) and catabolism (waste out)
That the Four Options are half anabolism (take in what nurtures, hold in what nurtures ) and half catabolism (block out what does not nurture, excrete out what does not nurture.)

That the origin of the two chemistries of catabolism and anabolism must be an adaptation to some dual cycle in the environment.
That the only such cycle in the environment is the light and dark, day and night cycle.
That the origin of catabolism and anabolism must be an adaptation to the light dark sun cycle.
That a possible scenario for the origin is a day night, light dark, cycle such that:
anabolic is Day, sunlight-UV, dry condensation synthesis type processes. And
catabolic is Night, No sunlight - UV, hydrolysis of ATP type chemistry.

That there may be some direction in natural selection.
That natural selection seems to always goes in one of two ways; either better catabolism or better anabolism.
That there may be a purpose to life - better anabolism and or better catabolism.
That anabolism and catabolism are kept relatively separate for the four billion years That life has existed, in order that each division can better regulate that side, and have more ability to evolve, and change, and adapt to the environment.
That anabolism and catabolism are under a type of 'symbiotic arms race' where the separate sides help spur each other to further development and improvement through natural selection.

For more on reasons why catabolic and anabolic often evolved separately, let me know.
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Postby Tom Hendricks » Mon Feb 22, 2010 11:59 pm

Since Darwin's major discovery, there has been a lot of emphasis on
replication: genes, DNA, etc.
What there has not been is an equal amount of emphasis on metabolism.
This set of ideas opens up that side of the coin.
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Postby Tom Hendricks » Mon Mar 01, 2010 12:25 pm

This quote from Paul Davies well sums up the importance of looking at
life as either catabolic or anabolic processes:

"There are two paths in investigating the world: the reductionist path
and the synthetic path.

I would add there are two paths to all life the reductionist path
(catabolic) and the synthetic path (anabolic).
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Postby Tom Hendricks » Mon Mar 01, 2010 12:29 pm

The catabolic anabolic split hypothesis may also help explain Cope's Rule about size increase in evolution.
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Postby Tom Hendricks » Fri Mar 05, 2010 9:27 pm

Before, I've suggested that a positive mutation on the Catabolic side
might spur the Anabolic side to catch up - or vice versa - a positive
mutation on the Anabolic side might spur the Catabolic side to catch
up. Thus for every positive mutation you have two improvements, and a
sort of motor to push natural selection. We have the term 'arms
race' , this would be a personal 'arms race' between the two
metabolic processes. But in this arms race, both would be positive
changes.

But what about the other way.
If there was a negative mutation on the Catabolic side might the
Anabolic side be able to sometimes fix or repair or lessen the damage.
This should also be true if the mutation was on the anabolic side.
Thus one side can help protect the other in cases of a negative
mutation.

Therefore we have two ways the anabolic catabolic split can help.
Positive mutation on one side will help foster a positive mutation on
the other.
Negative mutation on one side will be lessened by the processes of the
other.
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Postby Tom Hendricks » Tue May 11, 2010 9:51 am

Here is a simple way to tell anabolic evolved processes from catabolic
evolved processes. It makes it easy for anyone to understand how the
two processes evolved, from catabolic and anabolic chemistry, and how
they evolved separately. It spells out the differences pretty
clearly.

Catabolic like processes, (that evolved from catabolic chemistry), are
all those that deal with NON-SELF : digestion, protection, waste out.

Anabolic like processes, that evolved from anabolic chemistry, are all
those that deal with SELF - all the rest of living processes.

Catabolic - NON SELF - break down of non self or self waste.
Anabolic - SELF - build up of self.

Thus when any living thing has pressure to deal with non self inside it or
outside it, it mostly uses processes that evolved from catabolic
chemistry.

When any living thing has pressure to deal with self, it mostly uses
processes that evolved from anabolic chemistry.

Now I think everyone should be able to clearly see my hypothesis.
Comments?
Last edited by Tom Hendricks on Sun Aug 15, 2010 10:20 pm, edited 1 time in total.
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Catabolic and Anabolic Hypothesis - May 2010

Postby Tom Hendricks » Sun May 16, 2010 11:15 pm

Statement of hypothesis so far.

Catabolic like processes and anabolic like processes have evolved from catabolic and anabolic chemistry. They have often evolved separately.

Catabolic like processes break down non self (or waste) (usually for one of these things, digestion, protection and/or waste out.)

Anabolic like processes build up self.
______________
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Clear Way to Test Hypothesis

Postby Tom Hendricks » Thu May 20, 2010 11:33 pm

How to test my hypothesis

"In any case of duplication one of the duplicates is free to undergo gene mutation because the necessary basic gene functions will be provided by the other copy. This provides an opportunity for divergence in the function of the duplicated genes, which could be advantageous in gene evolution." Modern Genetic Analysis by G,G,M,L

First a recap. My hypothesis suggests these two things:
1. catabolic chemistry evolved to Catabolic Like Processes that break down non-self.
(that often includes processes of digestion, protection, and waste out), and
anabolic chemistry evolved to Anabolic LIke Processes that build up self.
AND
2. catabolic and anabolic like processes sometimes evolved separately.

For my hypothesis to be true, and specifically for catabolic like processes to have evolved from basic catabolic chemistry; we should expect to see remnants of basic catabolic genes in catabolic like processes that break down non-self. For example digestion genes should have the remnants of the same genes for basic catabolic processes. That is something that can be tested.

OR

By accepting the hypothesis that basic catabolic genes evolved to catabolic like processes that attack non self; we should be able to see how those basic catabolic genes evolved over time to those such as digestion, protection, and waste out.
We should be able to have a history of how those genes changed over time and in different species, etc.

We now can test the hypothesis by 1. finding basic catabolic genes. 2 compare them with catabolic like processes that break down non self. 3. If correct we should find that the basic catabolic genes should be a major part of the evolved catabolic like processes.

Who knows about basic catabolic genes?
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More Support

Postby Tom Hendricks » Tue May 25, 2010 11:24 am

Support for my hypothesis that Catabolic Processes have often Evolved Separately. This post looks at

histocompatibility complex
immunoglobulin superfamily
mitochondria

Here are three examples that show that catabolic chemistry has evolved to
CATABOLIC LIKE PROCESSES THAT BREAK DOWN NON-SELF in ways mostly connected to DIGESTION, PROTECTION, and WASTE OUT, and that these are amazingly separate from anabolic processes:


Histocompatibility complex. "The major histocompatibility complex (MHC) is a large genomic region or gene family found in most vertebrates, it contains 128 genes. It is the most gene-dense region of the mammalian genome and it plays an important role in the immune system and autoimmunity."
http://genome.wellcome.ac.uk/doc_WTD020754.html
http://en.wikipedia.org/wiki/Major_hist ... ty_complex


Immunoglobulin superfamily. protein family that are mostly associated with the immunity system.
http://en.wikipedia.org/wiki/Immunoglobulin_superfamily

Mitochondria. Note that the mitochondria is the power for the cell, and that it is separate, and even has separate DNA and some genes.



-------------------------------------------------

Support for my hypothesis that Catabolic Processes have often Evolved Separately. This post looks at

Plasmids

Here is another example that shows that catabolic chemistry has evolved to
CATABOLIC LIKE PROCESSES THAT BREAK DOWN NON-SELF in ways mostly connected to DIGESTION, PROTECTION, and WASTE OUT, and that these are amazingly separate from anabolic processes:

Plasmids. Bacterial plasmids have separate DNA from the main bacterial genome, and their function is almost always catabolic like processes. Note these quotes on plasmids. Keep in mind these keywords from my hypothesis: digestion, protection, waste out. Note how small a role anabolic processes play in plasmids.

The genetic information transferred is often beneficial to the recipient cell. Benefits may include antibiotic resistance, other xenobiotic tolerance, or the ability to utilize a new metabolite.[6] Such beneficial plasmids may be considered bacterial endosymbionts. Some conjugative elements may also be viewed as genetic parasites on the bacterium, and conjugation as a mechanism that was evolved by the mobile element to spread itself into new hosts.


Another way to classify plasmids is by function. There are five main classes:

Fertility-F-plasmids, which contain tra-genes. They are capable of conjugation (transfer of genetic material between bacteria which are touching).
Resistance-(R)plasmids, which contain genes that can build a resistance against antibiotics or poisons and help bacteria produce pili. Historically known as R-factors, before the nature of plasmids was understood.
Col-plasmids, which contain genes that code for (determine the production of) bacteriocins, proteins that can kill other bacteria.
Degradative plasmids, which enable the digestion of unusual substances, e.g., toluene or salicylic acid.
Virulence plasmids, which turn the bacterium into a pathogen (one that causes disease).
Plasmids can belong to more than one of these functional groups.


Plasmids are subgrouped into five main types based on phenotypic function. R plasmids carry genes encoding resistance to antibiotics. Col plasmids confer on their host the ability to produce antibacterial polypeptides called bacteriocins that are often lethal to closely related or other bacteria. The col proteins of E. coli are encoded by plasmids such as ColE1. F plasmids contain the F or fertility system required for conjugation (the transfer of genetic information between two cells). These are also known as episomes because, under some circumstances, they can integrate into the host chromosome and thereby promote the transfer of chromosomal DNA between bacterial cells. Degradative or catabolic plasmids allow a host bacterium to metabolize normally undegradable or difficult compounds such as various pesticides. Finally, virulence plasmids confer pathogenicity on a host organism by the production of toxins or other virulence factors.
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Postby Tom Hendricks » Fri May 28, 2010 12:31 pm

Catabolic and Anabolic are connected but separate chemistries. This would suggest that these two separate chemistries could sometimes EVOLVE to other
Catabolic-like processes or anabolic-like processes,

The support evidence seems pretty strong and obvious. While the basic catabolic and anabolic chemistries are preserved, evolved forms can alter to separate catabolic like an anabolic like processes. These may include but not be limited to these.

We have catabolic and anabolic chemistries that are separate and regulated separately.

We have some separate organelles like the catabolic like mitochondria that are kept separate in the cell.

We have some DNA that is separate whether its in the mitochondria, or in bacteria plasmids for example.

We have some gene groups that are separate like the major histocompatibility complex with its catabolic like processes.

We have organs that are separate - stomach for catabolic breakdown, intestines for anabolic absorption. Catabolic like white blood cells , anabolic like red blood cells.

We have two sexes.
-------------------------------

Here are some support quotes.

Although anabolism and catabolism occur simultaneously in the cell, the rates of their chemical reactions are controlled independently of each other. For example, there are two enzymatic pathways for glucose metabolism. The anabolic pathway synthesizes glucose, while catabolism breaks down glucose. The two pathways share 9 of the 11 enzymatic steps of glucose metabolism, which can occur in either sequence (i.e., in the direction of anabolism or catabolism). However, two steps of glucose anabolism use an entirely different set of enzyme-catalyzed reactions.

There are two important reasons that the cell must have separate complementary anabolic and catabolic pathways. First, catabolism is a so-called "downhill" process during which energy is released, while anabolism requires the input of energy, and is therefore an energetically "uphill" process. At certain points in the anabolic pathway, the cell must put more energy into a reaction than is released during catabolism. Such anabolic steps require a different series of reaction than are used at this point during catabolism.

Second, the different pathways permit the cell to control the anabolic and catabolic pathways of specific molecules independently of each other. This is important because there are times when the cell must slow or halt a particular catabolic or anabolic pathway in order to reduce breakdown or synthesis of a particular molecule. If both anabolism and catabolism used the same pathway, the cell would not be able control the rate of either process independent of the other: slowing the rate of catabolism would slow the rate of anabolism.

Opposite anabolic and catabolic pathways can occur in different parts of the same cell. For example, in the liver the breakdown of fatty acids to the molecule acetyl-CoA takes place inside mitochondria. Mitochondria are the tiny, membrane-bound organelles that function as the cell's major site of ATP production. The buildup of fatty acids from acetyl-CoA occurs in the cytosol of the cell, that is, in the aqueous area of the cell that contains various solutes.
From:
http://science.jrank.org/pages/319/Anabolism.html

--------------------------------------------------------------------------------------
"Chemical chaos would result if all of a cell's metabolic pathways
were open simultaneously. Imagine, for example, a substance
synthesized by one pathway and broken down by another. If the two
pathways were to run at the same time, the cell would be spinning its
metabolic wheels. actually, the operation of each metabolic pathway is
tightly regulated. Pathways are switched on and off by controlling
enzyme activity....
Even when the enzymes for a metabolic pathway are individually
dissolved, they may be highly concentrated along with their substrates
within specialized organelles of the cell.... If the cell had the same
number of enzymes for respiration , but they were diluted throughout
the entire volume of the cell, respiration would be very inefficient."
Campbell


""Catabolic and anabolic pathways differ. If a metabolite is converted
to another metabolite by an exergonic process, free energy must be
supplied to convert the second metabolite back to the first. This
energetically "uphill" process requires a different pathway for at
least some of the reaction steps.
The existence of independent interconversion routes ... is an
important property of metabolic pathways because it allows independent
control of the two processes. If metabolite 2 is required by the cell,
it is necessary to 'turn off' the pathway from 2 to 1 while 'turning
on' the pathway from 1 to 2. Such independent control would be
impossible without different pathways." Voet, Voet, Pratt.

--------------------------
MORE SUPPORT

Many of the reactions of metabolism occur in series known as metabolic pathways. Molecules that enter these pathways are modified at each step of the pathways with the help of the enzymes. Some of the pathways are anabolic, using energy to build structures, whereas others are catabolic, breaking down large molecules into smaller ones and releasing energy.

Anabolic and catabolic processes occur in different cellular organelles. An example of organelles is the endoplasmic reticulum, which is a maze of internal membranes. One type of endoplasmic reticulum specializes in fat synthesis. Other type is converted with organelles called ribosomes, which are the site of the protein synthesis. An example of catabolic organelles is the lysosomes, which act as a kind of digestive system for the cell. Lysosomes contain enzymes capable of breaking down carbohydrates, fats, proteins, and other types of molecules that originate both inside and outside of the cell.

The mitochondrion is a catabolic organelle that contains energy from carbohydrates, fats, and proteins by cellular respiration. This process completely metabolizes these macronutrients in the presence of oxygen to produce carbon dioxide, water, and a form of energy that can be used by cells called ATP (adenosine triphosphate). The chemical bonds of ATP are very high in energy, and when they break, the energy is released. The energy contained in ATP can be used to do work or to synthesize new molecules.

Lysosomes as example of catabolic like processes (remember the major three catabolic like processes : digestion, protection, waste out while reading this).

Lysosomes are the cells' garbage disposal system. They are used for the digestion of macromolecules from phagocytosis (ingestion of other dying cells or larger extracellular material, like foreign invading microbes), endocytosis (where receptor proteins are recycled from the cell surface), and autophagy (wherein old or unneeded organelles or proteins, or microbes that have invaded the cytoplasm are delivered to the lysosome). Autophagy may also lead to autophagic cell death, a form of programmed self-destruction, or autolysis, of the cell, which means that the cell is digesting itself.

Other functions include digesting foreign bacteria (or other forms of waste) that invade a cell and helping repair damage to the plasma membrane by serving as a membrane patch, sealing the wound. In the past, lysosomes were thought to kill cells that were no longer wanted, such as those in the tails of tadpoles or in the web from the fingers of a 3- to 6-month-old fetus. While lysosomes digest some materials in this process, it is actually accomplished through programmed cell death, called apoptosis.[3][4]
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Postby maxwell » Thu Jun 03, 2010 1:37 am

a) it must be lonely for you. sometimes. sad.
b) Robert Anton Wilson's eight circuit theory of brain and behavioral development would be of interest to you and would probably augment your existing set of theories, which don't seem illogical.
c) western science refuses to acknowledge the great tool of Intuition in its' scientific method, so...it would appear that the choking to death of the West on its own arrogance and waste heat continues apace. It is really too bad.
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Postby maxwell » Thu Jun 03, 2010 1:38 am

Timothy Leary's Eight Circuits of Consciousness
From Robert Anton Wilson's
Cosmic Trigger: Final Secret of the Illuminati


Tunnel-Realities and Imprints
Let's try Dr. Leary's perspective on these mysteries.

To understand neurological space, Dr. Leary assumes that the nervous system consists of eight potential circuits, or "gears," or mini-brains. Four of these brains are in the usually active left lobe and are concerned with our terrestrial survival; four are extraterrestrial, reside in the "silent" or inactive right lobe, and are for use in our future evolution. This explains why the right lobe is usually inactive at this stage of our development, and why it becomes active when the person ingests psychedelics.

We will explain each of the eight "brains" briefly.



I. THE BIO-SURVIVAL CIRCUIT
This invertebrate brain was the first to evolve (2 to 3 billion years ago) and is the first activated when a human infant is born. It programs perception onto an either-or grid divided into nurturing-helpful Things (which it approaches) and noxious-dangerous Things (which it flees, or attacks). The imprinting of this circuit sets up the basic attitude of trust or suspicion which will ever after trigger approach or avoidance.


II. THE EMOTIONAL CIRCUIT
This second, more advanced bio-computer formed when vertebrates appeared and began to compete for territory (perhaps 500,000,000 B.C.). In the individual, this bigger tunnel-reality is activated when the DNA master-tape triggers the metamorphosis from crawling to walking. As every parent knows, the toddler is no longer a passive (bio-survival) infant but a mammalian politician, full of physical (and psychic) territorial demands, quick to meddle in family business and decision-making. Again the first imprint on this circuit remains constant for life (unless brainwashed) and identifies the stimuli which will automatically trigger dominant, aggressive behavior or submissive, cooperative behavior. When we say that a person is behaving emotionally, egotistically or 'like a two-year-old,' we mean that s/he is blindly following one of the tunnel-realities imprinted on this circuit.


III. THE DEXTERITY-SYMBOLISM CIRCUIT
This third brain was formed when hominid types began to differentiate from other primate stock (circa 4-5 million B.C.) and is activated for the linear left-lobe functions of the brain, determines our normal modes of artifact-manufacture and conceptual thought, i.e., third circuit 'mind.'

It is no accident, then, that our logic (and our computer-design) follows either-or, binary structure of these circuits. Nor is it an accident that our geometry, until the last century, has been Euclidean. Euclid's geometry, Aristotle's logic and Newton's physics are meta-programs synthesizing and generalizing first brain forward-back, second brain up-down and third brain right-left programs.



IV. THE SOCIAL-SEXUAL CIRCUIT
The fourth brain, dealing with the transmission of tribal or ethnic culture across generations, introduces the fourth dimension, time.

Since each of these tunnel-realities consists of biochemical imprints or matrices in the nervous system, each of them is specifically triggered by neuro-transmitters and other drugs.

NOTICE how drugs that stimulate the first four circuits, which are already activated, tend to be dangerously addictive, roughly ordered ascending from the first circuit. -deoxy

To activate the first brain take an opiate. Mother Opium and Sister Morphine bring you down to cellular intelligence, bio-survival passivity, the floating consciousness of the newborn. (This is why Freudians identify opiate addiction with the desire to return to infancy.)

To activate the second tunnel-reality, take an abundant quantity of alcohol. Vertebrate territorial patterns and mammalian emotional politics immediately appear when the booze flows, as Thomas Nashe intuitively realized when he characterized the various alcohol states by animal labels: "ass drunk," "goat drunk," "swine drunk," "bear drunk," etc.

To activate the third circuit, try coffee or tea, a high-protein diet, speed or cocaine.

The specific neurotransmitter for circuit four has not been synthesized yet, but it is generated by the glands after pubescence and flows volcanically through the bloodstreams of adolescents.

NONE OF THESE TERRESTRIAL DRUGS CHANGE BASIC BIOCHEMICAL IMPRINTS. The behaviors which they trigger are those which were wired into the nervous system during the first stages of imprint vulnerability. The circuit II drunk exhibits the emotional games or cons learned from parents in infancy. The circuit III "mind" never gets beyond the permutations and combinations of those tunnel-realities originally imprinted, or abstractions associated with the imprints through later conditioning. And so forth.

But all this Pavlovian-Skinnerian robotism changes drastically and dramatically when we turn to the right lobe, the future circuits and extraterrestrial chemicals.
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Postby maxwell » Thu Jun 03, 2010 1:39 am

The four evolving future 'brains' are:


V. THE NEUROSOMATIC CIRCUIT
When this fifth "body-brain" is activated, flat Euclidean figure-ground configurations explode multi-dimensionally. Gestalts shift, in McLuhan's terms, from linear VISUAL SPACE to all-encompassing SENSORY SPACE. A hedonic turn-on occurs, a rapturous amusement, a detachment from the previously compulsive mechanism of the first four circuits. I turned this circuit on with pot and Tantra.

This fifth brain began to appear about 4,000 years ago in the first leisure-class civilizations and has been increasing statistically in recent centuries (even before the Drug Revolution), a fact demonstrated by the hedonic art of India, China, Rome and other affluent societies. More recently, Ornstein and his school have demonstrated with electroencephalograms that this circuit represents the first jump from the linear left lobe of the brain to the analogical right lobe.

The opening and imprinting of this circuit has been the preoccupation of "technicians of the occult"—Tantric shamans and hatha yogis. While the fifth tunnel-reality can be achieved by sensory deprivation, social isolation, physiological stress or severe shock (ceremonial terror tactics, as practiced by such rascal-gurus as Don Juan Matus or Aleister Crowley), it has traditionally been reserved to the educated aristocracy of leisure societies who have solved the four terrestrial survival problems.

About 20,000 years ago, the specific fifth brain neurotransmitter was discovered by shamans in the Caspian Sea area of Asia and quickly spread to other wizards throughout Eurasia and Africa. It is, of course, cannabis. Weed. Mother Mary Jane.

It is no accident that the pot-head generally refers to his neural state as "high" or "spaced-out." The transcendence of gravitational, digital, linear, either-or, Aristotelian, Newtonian, Euclidean, planetary orientations (circuits I-IV) is, in evolutionary perspective, part of our neurological preparation for the inevitable migration off our home planet, now beginning. This is why so many pot-heads are STAR TREK freaks and science fiction adepts. (Berkeley, California, certainly the Cannabis Capital of the U.S., has a Federation Trading Post on Telegraph Avenue, where the well-heeled can easily spend $500 or more in a single day, buying STAR TREK novels, magazines, newsletters, bumper stickers, photographs, posters, tapes, etc., including even complete blueprints for the starship ENTERPRISE.)

The extraterrestrial meaning of being "high" is confirmed by astronauts themselves; 85% of those who have entered the free-fall zero gravity describe "mystic experiences" or rapture states typical of the neurosomatic circuit. "No photo can show how beautiful Earth looked," raves Captain Ed Mitchell, describing his Illumination in free-fall. He sounds like any successful yogi or pot-head. No camera can show this experience because it is inside the nervous system.

FREE-FALL, AT THE PROPER EVOLUTIONARY TIME, TRIGGERS THE NEUROSOMATIC MUTATION, Leary believes. Previously this mutation has been achieved "artificially" by yogic or shamanic training or by the fifth circuit stimulant, cannabis. Surfing, skiing, skin-diving and the new sexual culture (sensuous massage, vibrators, imported Tantric arts, etc.) have evolved at the same time as part of the hedonic conquest of gravity. The Turn-On state is always described as "floating," or, in the Zen metaphor, "one foot above the ground."


VI. THE NEUROELECTRIC CIRCUIT
The sixth brain consists of the nervous system becoming aware of itself apart from imprinted gravitational reality-maps (circuits I-IV) and even apart from body-rapture (circuit V). Count Korzybski, the semanticist, called this state "consciousness of abstracting." Dr. John Lilly calls it "metaprogramming," i.e., awareness of programming one's programming. This Einsteinian, relativistic contelligence (consciousness-intelligence) recognizes, for instance, that the Euclidean, Newtonian and Aristotelian reality-maps are just three among billions of possible programs or models for experience. I turned this circuit on with Peyote, LSD and Crowley's "magick" metaprograms.

This level of brain-functioning seems to have been reported first around 500 B.C. among various "occult" groups connected by the Silk Route (Rome-North India). It is so far beyond the terrestrial tunnel-realities that those who have achieved it can barely communicate about it to ordinary humanity (circuits I-IV) and can hardly be understood even by fifth circuit Rapture Engineers.

The characteristics of the neuroelectric circuit are high velocity, multiple choice, relativity, and the fission-fusion of all perceptions into parallel science-fiction universes of alternate possibilities.

The mammalian politics which monitor power struggles among terrestrial humanity are here transcended, i.e., seen as static, artificial, an elaborate charade. One is neither coercively manipulated into another's territorial reality nor forced to struggle against it with reciprocal emotional game-playing (the usual soap-opera dramatics). One simply elects, consciously, whether or not to share the other's reality-model.

Tactics for opening and imprinting the sixth circuit are described and rarely experienced in advanced rajah yoga, and in the hermetic (coded) manuals of the medieval-Renaissance alchemists and Illuminati.

No specific sixth circuit chemical is yet available, but strong psychedelics like mescaline (from my 1962-63 "sacred cactus," peyotl) and psilocybin (from the Mexican "magic mushroom," teonactl) open the nervous system to a mixed-media series of circuit V and circuit VI channels. This is appropriately called "tripping," as distinguished from straight-forward fifth circuit "turning on" or "getting high."

The suppression of scientific research in this area has had the unfortunate result of turning the outlaw drug culture back toward fifth circuit hedonics and pre-scientific tunnel-realities (the occult revival, solipsism, Pop Orientalism). Without scientific discipline and methodology, few can successfully decode the often-frightening (but philosophically crucial) sixth circuit metaprogramming signals. Such scientists as do continue to study this subject dare not publish their results (which are illegal) and record ever-wider tunnel-realities only in private conversations—like the scholars of the Inquisitorial era. (Voltaire announced the Age of Reason two centuries too soon. We are still in the Dark Ages.) Most underground alchemists have given up on such challenging and risky self-work and restrict their trips to fifth circuit erotic tunnels.

The evolutionary function of the sixth circuit is to enable us to communicate at Einsteinian relativities and neuro-electric accelerations, not using third circuit laryngeal-manual symbols but directly via feedback, telepathy and computer link-up. Neuro-electric signals will increasingly replace "speech" (hominid grunts) after space migration.

When humans have climbed out of the atmosphere-gravity well of planetary life, accelerated sixth circuit contelligence will make possible high-energy communication with "Higher Intelligences," i.e., ourselves-in-the-future and other post-terrestrial races.

It is charmingly simple and obvious, once we realize that the spaced-out neural experiences really are extraterrestrial, that getting high and spacing out are accurate metaphors. Circuit V neurosomatic rapture is preparation for the next step in our evolution, migration off the planet. Circuit VI is preparation for the step after that, interspecies communication with advanced entities possessing electronic (post-verbal) tunnel-realities.

Circuit VI is the "universal translator" often imagined by science-fiction writers, already built into our brains by the DNA tape. Just as the circuits of the future butterfly are already built into the caterpillar.



VII. THE NEUROGENETIC CIRCUIT
The seventh brain kicks into action when the nervous system begins to receive signals from WITHIN THE INDIVIDUAL NEURON, from the DNA-RNA dialogue. The first to achieve this mutation spoke of "memories of past lives," "reincarnation," "immortality," etc. That these adepts were recording something real is indicated by the fact that many of them (especially Hindu and Sufis) gave marvelously accurately poetic vistas of evolution 1,000 or 2,000 years before Darwin, and foresaw Superhumanity before Nietzsche.

The "akashic records" of Theosophy, the "collective unconscious" of Jung, the "phylogenetic unconscious" of Grof and Ring, are three modern metaphors for this circuit. The visions of past and future evolution described by those who have had "out-of-body" experiences during close-to-death episodes also describes the trans-time circuit VII tunnel-reality.

Specific exercises to trigger circuit VII are not to be found in yogic teaching; it usually happens, if at all, after several years of the kind of advanced rajah yoga that develops circuit VI facility.

The specific circuit VII neurotransmitter is, of course LSD. (Peyote and psilocybin produce some circuit VII experiences also.)

Circuit VII is best considered, in terms of 1977 science, as the genetic archives, activated by anti-histone proteins. The DNA memory coiling back to the dawn of life. A sense of the inevitability of immortality and interspecies symbiosis comes to all circuit VII mutants; we now see that this, also, is an evolutionary forecast, since WE STAND RIGHT NOW ON THE DOOR-STEP OF EXTENDED LONGEVITY LEADING TO IMMORTALITY.

The exact role of the right-lobe circuits and the reason for their activation in the 1960s cultural revolution now becomes clear. As sociologist F.M. Esfandiary writes in UPWINGERS, "Today when we speak of immortality and of going to another world we no longer mean these in a theological or metaphysical sense. People are now traveling to other worlds. People are now striving for immortality. Transcendence is no longer a metaphysical concept. It has become reality."

The evolutionary function of the seventh circuit and its evolutionary, aeon-spanning tunnel-reality is to prepare us for conscious immortality and interspecies symbiosis.


VIII. THE NEURO-ATOMIC CIRCUIT
Hold on to your hats and breathe deeply—this is the farthest-out that human intelligence has yet ventured.

Consciousness probably precedes the biological unit or DNA tape-loop. "Out-of-body experiences," "astral projection," contact with alien (extraterrestrial?) "entities" or with a galactic Overmind, etc., such as I've experienced, have all been reported for thousands of years, not merely by the ignorant, the superstitious, the gullible, but often by the finest minds among us (Socrates, Giordano Bruno, Edison, Buckminster Fuller, etc.). Such experiences are reported daily to parapsychologists and have been experienced by such scientists as Dr. John Lilly and Carlos Castaneda. Dr. Kenneth Ring has attributed these phenomena to what he calls, very appropriately, "the extraterrestrial unconscious."

Dr. Leary suggests that circuit VIII is literally neuro-atomic—infra, supra and meta-physiological—a quantum model of consciousness and/or a conscious model of quantum mechanics by the turned-on physicists discussed previously (Prof. John Archibald Wheeler, Saul-Paul Sirag, Dr. Fritjof Capra, Dr. Jack Sarfatti, etc.) indicates strongly that the "atomic consciousness" first suggested by Leary in "The Seven Tongues of God" (1962) is the explanatory link which will unite parapsychology and paraphysics into the first scientific empirical experimental theology in history.

When the nervous system is turned on to this quantum-level circuit, space-time is obliterated. Einstein's speed-of-light barrier is transcended; in Dr. Sarfatti's metaphor, we escape "electromagnetic chauvinism." The contelligence within the quantum projection booth IS the entire cosmic "brain," just as the micro-miniaturized DNA helix IS the local brain guiding planetary evolution. As Lao-tse said from his own Circuit VIII perspective, "The greatest is within the smallest."

Circuit VIII is triggered by Ketamine, a neuro-chemical researched by Dr. John Lilly, which is also (according to a wide-spread but unconfirmed rumor) given to astronauts to prepare them for space. High doses of LSD also produce some circuit VIII quantum awareness.

This neuro-atomic contelligence is four mutations beyond terrestrial domesticity. (The current ideological struggle is between circuit IV tribal moralists-or-collectivists and circuit V hedonic individualists.) When our need for higher intelligence, richer involvement in the cosmic script, further transcendence, will no longer be satisfied by physical bodies, not even by immortal bodies hopping across space-time at Warp 9, circuit VIII will open a further frontier. New universes and realities. "Beyond theology: the science and art of Godmanship," as Alan Watts once wrote.

It is therefore possible that the mysterious "entities" (angels and extraterrestrials) monotonously reported by circuit VIII visionaries are members or races already evolved to this level. But it is also possible, as Leary and Sarfatti more recently suggest, that They are ourselves-in-the-future.

The left-lobe terrestrial circuits contain the learned lessons of our evolutionary past (and present). The right-lobe extraterrestrial circuits are the evolutionary script for out future.

Thus far, there have been two alternative explanations of why the Drug Revolution happened. The first is presented in a sophisticated way by anthropologist Weston LaBarre, and in an ignorant, moralistic way by most anti-drug propaganda in the schools and mass media. This explanation says, in essence, that millions have turned away from the legal DOWN drugs to illegal HIGH drugs because we are living in troubled times and many are seeking escape into fantasy.

This theory, at its best, only partially explains the ugliest and most publicized aspect of the revolution—the reckless drug abuse characteristic of the immature. It says nothing about the millions of respectable doctors, lawyers, engineers, etc., who have turned away from second circuit intoxication with booze to fifth circuit rapture with weed.

Nor does it account at all for the thoughtful, philosophical sixth circuit investigations of persons of high intelligence and deep sensibility, such as Aldous Huxley, Dr. Stanley Grof, Masters-Houston, Alan W. Watts, Carlos Castaneda, Dr. John Lilly and thousands of scientific and lay researchers on consciousness.

A more plausible theory, devised by psychiatrist Norman Zinberg out of the work of Marshall McLuhan, holds that modern electronic media have so shifted the nervous system's parameters that young people no longer enjoy "linear" drugs like alcohol and find meaning only in "non-linear" weed and psychedelics.

This is certainly part of the truth, but it is too narrow and overstresses TV and computers without sufficiently stressing the general technological picture—the ongoing Science-Fiction Revolution of which the most significant aspects are Space Migration, Increased Intelligence and Life Extension, which Leary has condensed into his SMI²LE formula.

Space Migration plus Increased Intelligence plus Life Extension means expansion of humanity into all space-time. SM + I² + LE = infinity.

Without totally endorsing Charles Fort's technological mysticism ("It steam-engines when it comes steam-engine time"), it is obvious that the DNA metaprogram for planetary evolution is far wiser than any of our individual nervous systems—which are, in a sense, giant robots or sensors for DNA. Early science-fiction of brilliant writers like Stapledon, Clarke, Heinlein; Kubrick's 2001—all were increasingly clear DNA signals transmitted through the intuitive right lobe of sensitive artists, preparing us for the extraterrestrial mutation.

It is scarcely coincidental that mainstream "literary" intellectuals—the heir of the Platonic-aristocratic tradition that a gentleman never uses his hands, monkeys with tools or learns a manual craft—despise both science-fiction and the dope culture. Nor is it coincidental that the WHOLE EARTH CATALOGS - created by Stewart Brand, a graduate of Ken Kesey's Merry Pranksters—are the New Testament of the rural drop-out culture, each issue bulging with tons of eco-technological information about all the manual, dextrous, gadgety know-how that Plato and his heirs consider fit only for slaves. Not surprisingly, Brand's latest publication, CO-EVOLUTION QUATERLY, has been devoted to publicizing Prof. Gerard O'Neill's space-habitat, L5.

Nor is it an accident that dopers seem to prefer science-fiction to any other reading, even including the extraterrestrial-flavored Hindu scriptures and occult-shamanic circuit VI-VIII trip-poets like Crowley and Hesse.

The circuit VI drugs may have contributed much to the metaprogramming consciousness that has led to sudden awareness of "male chauvinism" (women's liberationists), "species chauvinism" (ecology, Lilly's dolphin studies), "type-G star chauvinism" (Carl Sagan), even "oxygen chauvinism" (the CETI conference), etc. The imprinted tunnel-realities which identify one as "white-male-American-earthian" etc. or "black-female-Cuban" etc. are no longer big enough to enclose our exploding contelligence.

As TIME magazine said on November 26, 1973, "Within ten years, according to pharmacologists, they will have perfected pills and cranial electrodes of providing life-long bliss for everyone on Earth." The 1960s hysteria about weed and acid was just the overture to this fifth circuit break-through. Nathan S. Kline, M.D., predicts real aphrodisiacs, drugs to speed up learning, drugs to foster or terminate any behavior. ... Those who were jailed or beaten by cops in the 1960s were forerunners of the Revolution of Inner Technology.

STAR TREK is a better guide to the emerging reality than anything in the NEW YORK REVIEW OF BOOKS. The life-support and defense-system engineer, Scotty (circuit I), the emotional-sentimental Dr. McCoy (circuit II), the logical science officer Mr. Spock (circuit III) and the alternately paternalistic and romantic Captain Kirk (circuit IV) are perpetually voyaging through our future neurological history and encountering circuit V, VI, VII, and VIII intelligences, however crudely presented.

In short, the various levels of consciousness and circuits we have been discussing, and illustrating, are all biochemical imprints in the evolution of the nervous system. Each imprint creates a bigger tunnel-reality. In the Sufi metaphor, the donkey on the which we ride becomes a different donkey after each imprint. The metaprogrammer continually learns more and is increasingly able to be aware of itself operating. We are thus evolving to intelligence-studying-intelligence (the nervous system studying the nervous system) and are more and more capable of accelerating our own evolution.

Leary now symbolizes intelligence-studying-intelligence by the mark, I². On the lower levels, you see with one "I", so to speak. On the higher levels, you see with many "I"s, and space-time shifts from three Euclidean dimensions to non-Euclidean multi-dimensionality.

By Robert Anton Wilson
The Eightfold Model of Human Consciousness
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Postby maxwell » Thu Jun 03, 2010 1:41 am

disclaimer:

I am just a fan of RAW and Timothy Leary. the militarization of space is a suicidal option -- and Star Trek geekery is almost completedly a pathetic waste of human intellect.

For the value judgments of 1966 to be forced on the world as a realistic summary of what life might be like in some 23rd century is actually sort of evil. Gene Roddenberry and his wife Majel were great writers. I wish people would let them rest.

It's really too bad.
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Two New Terns - Constructive and Deconstructive Biology

Postby Tom Hendricks » Fri Jun 04, 2010 4:09 pm

CONSTRUCTIVE = evolved anabolic processes
DECONSTRUCTIVE = evolved catabolic processes.

The Hypothesis: Metabolism is catabolic and anabolic chemistry.
This hypothesis suggests that as the basic chemistries remained very little changed over time, they

1. evolved to new processes (perhaps through duplication of genes) and
2. evolved separately in many cases, and
3. looking at life as often two main threads of these evolved processes, gives new insights into life.

Catabolic chemistry, while retaining its basic chemical processes, also evolved to some DECONSTRUCTIVE processes mostly concerned with breaking down NON-SELF. Mostly in DIGESTION, PROTECTION and WASTE OUT. See the long list of examples through these many related posts.

Anabolic chemistry, while retaining its basic chemical processes, also evolved to some CONSTRUCTIVE processes mostly concerned with building up self.
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